Examples: breast cancer, NCT03147287, pd-l1

Top 100 results for: "triple negative breast cancer"

Enrolling

A Phase I Study of Niraparib Administered Concurrently with Postoperative RT in Patients with Triple Negative Breast Cancer with an Incomplete Pathologic Response

Trial Description: This research study involves Niraparib as a possible treatment for triple negative breast cancer.

  • Conditions: residual disease, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03945721
  • Protocol ID: 19-055

Not Enrolling

Combination Ipatasertib and Atezolizumab to Prevent Recurrence in Triple Negative Breast Cancer

Trial Description: The purpose of this study is to determine if a combination of two drugs ipatasertib and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulating tumor DNA in the blood. This research study involves the following investigational drugs: - Sacituzumab govitecan - Atezolizumab

  • Conditions: breast cancer, circulating tumor dna, residual cancer, triple negative breast cancer
  • Phase: II
  • Trial ID: NCT04434040
  • Protocol ID: 20-028

Enrolling

A Phase IB/II, 2-Stage, Open-label, Multicenter Study to Determine the Efficacy and Safety of Durvalumab (MEDI4736) + Paclitaxel and Durvalumab (MEDI4736) in Combination With Novel Oncology Therapies With or Without Paclitaxel for First-line Metastatic Triple Negative Breast Cancer

Trial Description: This study is designed to determine the efficacy and safety of durvalumab in combination with novel oncology therapies with or without paclitaxel and durvalumab + paclitaxel for first-line metastatic triple negative breast cancer

  • Conditions: triple negative breast neoplasms
  • Phase: I/II
  • Trial ID: NCT03742102
  • Protocol ID: 21-198

Not Enrolling

A Phase 1b Study of Safety and Immune Response to PVX-410 Vaccine Alone and in Combination with Pembrolizumab in HLA-A2+ Patients with Metastatic Triple Negative Breast Cancer (TNBC)

Trial Description: This research study is studying immunotherapy as a possible treatment for metastatic Triple Negative Breast Cancer (TNBC) in participants who are HLA-A2+. The drugs involved in this study are: - PVX-410 - Pembrolizumab - Hiltonol - Montanide

  • Conditions: metastatic breast cancer, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03362060
  • Protocol ID: 17-328

Not Enrolling

A phase 2 study of response-guided neoadjuvant sacituzumab govitecan (IMMU-132) in patients with localized Triple-Negative Breast Cancer (NeoSTAR). A phase 2 study of response-guided neoadjuvant sacituzumab govitecan (IMMU-132) in patients with localized Triple-Negative Breast Cancer (NeoSTAR).

Trial Description: This research study is studying to evaluate sacituzumab govitecan for individuals with localized triple negative breast cancer (TNBC) The names of the study drugs involved in this study is: - Sacituzumab govitecan (SG) - Pembrolizumab (combination therapy with SG)

  • Conditions: er-negative breast cancer, her2-negative breast cancer, invasive breast cancer, pr-negative breast cancer, triple negative breast cancer
  • Phase: II
  • Trial ID: NCT04230109
  • Protocol ID: 19-578

Enrolling

Phase 1b/2 Study to Evaluate Safety and Anti-Tumor Activity of Antibody-Drug Conjugate Sacituzumab Govitecan in Combination with the Poly (Adenosine Diphosphate [ADP]-Ribose) Polymerase (PARP) Inhibitor Talazoparib in Patients with Metastatic Triple-Negative Breast Cancer

Trial Description: This research is studying the effect of Antibody-Drug Conjugate Sacituzumab Govitecan in Combination with the Poly (Adenosine Diphosphate [ADP]-Ribose) Polymerase (PARP) Inhibitor Talazoparib in Patients with Metastatic Triple-Negative Breast Cancer.

  • Conditions: breast cancer
  • Phase: I/II
  • Trial ID: NCT04039230
  • Protocol ID: 19-239

Not Enrolling

A randomized phase II trial of carboplatin with or without nivolumab in first-line metastatic triple-negative breast cancer

Trial Description: This research study is studying a drug called Carboplatin with or without another study drug, Nivolumab as a possible treatment for triple-negative breast cancer that has spread to other parts of the body. The interventions involved in this study are: - Carboplatin - Nivolumab

  • Conditions: breast cancer
  • Phase: II
  • Trial ID: NCT03414684
  • Protocol ID: 17-512

Not Enrolling

A phase II study of atezolizumab in combination with stereotactic radiation for patients with triple-negative breast cancer and brain metastasis

Trial Description: This research study is studying the combination of a drug called atezolizumab and a radiation procedure called stereotactic radiosurgery (SRS) as a possible treatment for triple-negative breast cancer that has spread to the brain. The interventions involved in this study are: - Atezolizumab - Stereotactic radiosurgery (SRS)

  • Conditions: breast cancer
  • Phase: II
  • Trial ID: NCT03483012
  • Protocol ID: 17-519

Enrolling

Saci-IO TNBC: Randomized phase II study of sacituzumab govitecan with or without pembrolizumab in PD-L1-negative metastatic triple negative breast cancer (TNBC)

Trial Description: This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts the body and is PD-L1-negative. The names of the study interventions involved in this study are: - Sacituzumab govitecan (Trodelvy™;IMMU-132) - Pembrolizumab (Keytruda®; MK-3475)

  • Conditions: breast cancer, pd-l1 negative, triple negative breast cancer
  • Phase: II
  • Trial ID: NCT04468061
  • Protocol ID: 20-166

Enrolling

"Double Blind, Parallel Groups, Controlled, Randomized Phase II Trial to Evaluate Vaccination with Folate Receptor Alpha Peptide Vaccine with GM-CSF as Vaccine Adjuvant Following Oral Cyclophosphamide Versus GM-CSF/Placebo to Prevent Recurrence in Patients with Triple Negative Breast Cancer"

Trial Description: This randomized phase II trial studies how well multi-epitope folate receptor alpha peptide vaccine, sargramostim (GM-CSF), and cyclophosphamide work to prevent the recurrence of stage 1-3 triple negative breast cancer. Vaccines made from a person's white blood cells mixed with tumor proteins may help the body build an effective immune response to kill tumor cells. Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving multi-epitope folate receptor alpha peptide vaccine, sargramostim (GM-CSF), and cyclophosphamide may work well together to prevent cancer recurrence after surgery and other standard treatments for triple negative breast cancer.

  • Conditions: bilateral breast carcinoma, breast inflammatory carcinoma, stage ib breast cancer ajcc v7, stage ii breast cancer ajcc v6 and v7, stage iia breast cancer ajcc v6 and v7, stage iib breast cancer ajcc v6 and v7, stage iii breast cancer ajcc v7, stage iiia breast cancer ajcc v7, stage iiib breast cancer ajcc v7, stage iiic breast cancer ajcc v7, triple-negative breast carcinoma, unilateral breast carcinoma
  • Phase: II
  • Trial ID: NCT03012100
  • Protocol ID: 18-078

Not Enrolling

A PHASE 1B/2 STUDY TO EVALUATE SAFETY AND ANTI-TUMOR ACTIVITY OF AVELUMAB IN COMBINATION WITH THE POLY (ADENOSINE DIPHOSPHATE [ADP]-RIBOSE) POLYMERASE (PARP) INHIBITOR TALAZOPARIB IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS

Trial Description: Avelumab in combination with talazoparib will be investigated in patients with locally advanced (primary or recurrent) or metastatic solid tumors, including non-small cell lung cancer (NSCLC), triple negative breast cancer (TNBC), hormone receptor positive (HR+) breast cancer, recurrent platinum sensitive ovarian cancer, urothelial cancer (UC), and castration resistant prostate cancer (CRPC).

  • Conditions: avelumab in combination with talazoparib will be investigated in patients with locally advanced (primary or recurrent) or metastatic solid tumors
  • Phase: I/II
  • Trial ID: NCT03330405
  • Protocol ID: 17-687

Not Enrolling

An International, Multi-Center, Open-Label, Randomized, Phase III Trial of Sacituzumab Govitecan versus Treatment of Physician Choice in Patients with Metastatic Triple-Negative Breast Cancer Who Received at Least Two Prior Treatments

Trial Description: The primary objective of this study is to compare the efficacy of sacituzumab govitecan to the treatment of physician's choice (TPC) as measured by independently-reviewed Independent Review Committee (IRC) progression-free survival (PFS) in participants with locally advanced or metastatic triple-negative breast cancer (TNBC) previously treated with at least two systemic chemotherapy regimens for unresectable, locally advanced or metastatic disease, and without brain metastasis at baseline.

  • Conditions: breast cancer
  • Phase: III
  • Trial ID: NCT02574455
  • Protocol ID: 17-495

Not Enrolling

A Randomized Phase III Post-Operative Trial of Platinum Based Chemotherapy Vs. Capecitabine in Patients with Residual Triple-Negative Breast Cancer following Neoadjuvant Chemotherapy

Trial Description: This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether cisplatin or carboplatin is more effective than capecitabine in treating patients with residual triple negative basal-like breast cancer.

  • Conditions: estrogen receptor negative, her2/neu negative, invasive breast carcinoma, progesterone receptor negative, stage ii breast cancer, stage iia breast cancer, stage iib breast cancer, stage iii breast cancer, stage iiia breast cancer, stage iiib breast cancer, stage iiic breast cancer, triple-negative breast carcinoma
  • Phase: III
  • Trial ID: NCT02445391
  • Protocol ID: 18-723

Not Enrolling

Phase Ib, open-label, multi-center study to characterize the safety, tolerability and pharmacodynamics (PD) of PDR001 in combination with CJM112, EGF816, Ilaris® (canakinumab) or Mekinist® (trametinib)

Trial Description: The purpose of this study is to combine the PDR001 checkpoint inhibitor with each of four agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety, tolerability, pharmacological and clinical activity of these combinations

  • Conditions: colorectal cancer triple negative breast cancer nsclc - adenocarcinoma
  • Phase: I
  • Trial ID: NCT02900664
  • Protocol ID: 16-479

Not Enrolling

A Phase Ib/II, open label, multicenter study of MCS110 in combination with PDR001 in patients with advanced malignancies

Trial Description: The purpose of this study of MCS110 with PDR001 was to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of the combination of MCS110 with PDR001 in adult patients with solid tumors

  • Conditions: endometrial carcinoma, melanoma, pancreatic carcinoma, triple negative breast cancer
  • Phase: I/II
  • Trial ID: NCT02807844
  • Protocol ID: 16-491

Not Enrolling

A Phase 1/2 Study of CT7001 in Combination with Fulvestrant in Patients with Metastatic or Locally Advanced Hormone-Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer

Trial Description: This is a modular, Phase I/II, multicentre study to investigate CT7001 monotherapy in advanced solid malignancies and to further investigate CT7001 as monotherapy or in combination with standard therapy in specific participant groups with Triple Negative Breast Cancer (TNBC), Castrate Resistant Prostate Cancer (CRPC) and in combination with fulvestrant for patients with hormone receptor-positive (HR+ve) / human epidermal growth factor-2 negative (HER2-ve) breast cancer.

  • Conditions: advanced solid malignancies
  • Phase: I/II
  • Trial ID: NCT03363893
  • Protocol ID: 19-827

Not Enrolling

A Phase 1 Study of PARP inhibitor olaparib and HSP90 inhibitor AT13387 for treatment of advanced solid tumors with expansion in patients with recurrent epithelial ovarian, fallopian tube, peritoneal cancer or recurrent triple-negative breast cancer

Trial Description: This phase I trial studies the side effects and best dose of olaparib and onalespib when given together in treating patients with solid tumors that have spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable) or ovarian, fallopian tube, primary peritoneal, or triple-negative breast cancer that has come back (recurrent). Olaparib and onalespib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

  • Conditions: metastatic high grade fallopian tube serous adenocarcinoma, metastatic malignant solid neoplasm, metastatic primary peritoneal serous adenocarcinoma, metastatic triple-negative breast carcinoma, platinum-resistant fallopian tube carcinoma, platinum-resistant ovarian carcinoma, platinum-resistant primary peritoneal carcinoma, recurrent breast carcinoma, recurrent high grade fallopian tube serous adenocarcinoma, recurrent high grade ovarian serous adenocarcinoma, recurrent primary peritoneal high grade serous adenocarcinoma, recurrent triple-negative breast carcinoma, refractory fallopian tube serous adenocarcinoma, refractory ovarian serous adenocarcinoma, refractory primary peritoneal serous adenocarcinoma, refractory triple-negative breast carcinoma, unresectable high grade fallopian tube serous adenocarcinoma, unresectable malignant solid neoplasm, unresectable primary peritoneal serous adenocarcinoma
  • Phase: I
  • Trial ID: NCT02898207
  • Protocol ID: 17-715

Not Enrolling

A Phase 1b/2, Open-label, Parallel Arm Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Oral Rucaparib in Combination with Other Anticancer Agents in Patients with a Solid Tumor

Trial Description: This is an open label, Phase 1b/2 study with multiple treatment arms evaluating the safety, tolerability, PK, and preliminary efficacy of rucaparib in combination with a second anticancer therapy in patients with an advanced/metastatic solid malignancy (Phase 1b), followed by evaluation of the combination in one or more specific patient populations in an expansion phase (Phase 2 cohorts

  • Conditions: ovarian cancer, solid tumor, triple-negative breast cancer, urothelial carcinoma
  • Phase: I/II
  • Trial ID: NCT03992131
  • Protocol ID: 19-168

Not Enrolling

A Phase 2 Study of abemaciclib for Patients with Retinoblastoma Positive, Triple-Negative Metastatic Breast Cancer

Trial Description: This research study is studying a drug called Abemaciclib as a possible treatment for have metastatic triple-negative type of breast cancer.

  • Conditions: breast cancer
  • Phase: II
  • Trial ID: NCT03130439
  • Protocol ID: 17-024

Enrolling

Phase 1, Two-Part, Multicenter, Open-Label, Multiple Dose, First-in-Human Study of DS-1062a in Subjects with Advanced Solid Tumors

Trial Description: This study is one single group of participants with non-small cell lung cancer (NSCLC) who have not been cured by other treatments. It is the first time the drug has been used in humans, and will be in two parts. The primary purpose of the parts are: - Dose Escalation: To investigate the safety and tolerability and to determine the maximum tolerated dose (MTD) and the recommended dose for expansion (RDE) of DS-1062a - Dose Expansion: To investigate the safety and tolerability of DS-1062a in additional solid tumors This study is expected to last approximately 6 years from

  • Conditions: hormone receptor positive breast cancer, non-small cell lung cancer, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03401385
  • Protocol ID: 18-061

Enrolling

A Phase 2, Open-Label Study to Evaluate the Safety and Antitumor Activity of CX-2009 in Advanced HR-Positive/HER2-Negative Breast Cancer and of CX-2009 as Monotherapy and in Combination with CX-072 in Advanced Triple-Negative Breast Cancer (CTMX-2009-002)

Trial Description: A Phase 2, clinical study in advanced, metastatic breast cancer that will evaluate CX-2009 monotherapy in both Hormone Receptor(HR) positive/HER2 negative breast cancer and in TNBC, and evaluate CX-2009+CX-072 in TNBC

  • Conditions: breast cancer, breast neoplasms, breast neoplasms hormone receptor positive/her2 negative, breast neoplasms triple-negative, neoplasms
  • Phase: II
  • Trial ID: NCT04596150
  • Protocol ID: 21-130

Not Enrolling

Phase II study of combination ruxolitinib (INCB018424) with preoperative chemotherapy for triple negative inflammatory breast cancer

Trial Description: This research study is studying Ruxolitinib as possible treatment for Inflammatory Breast Cancer (IBC). The Following drugs will be use in combination with Ruxolinitinib. - Paclitaxel (also called Taxol) - Doxorubicin also called Adriamycin - Cyclophosphamide, also called Cytoxan

  • Conditions: inflammatory breast cancer (ibc)
  • Phase: II
  • Trial ID: NCT02876302
  • Protocol ID: 16-151

Not Enrolling

Phase Ib, open-label, multi-center study to characterize the safety, tolerability and pharmacodynamics (PD) of PDR001 in combination with LCL161, everolimus (RAD001) or panobinostat (LBH589)

Trial Description: The purpose of this study is to combine the PDR001 checkpoint inhibitor with several agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety, tolerability, pharmacological and clinical activity of these combinations

  • Conditions: colorectal cancer non-small cell lung carcinoma (adenocarcinoma) triple negative breast cancer renal cell carcinoma
  • Phase: I
  • Trial ID: NCT02890069
  • Protocol ID: 16-423

Enrolling

Phase 1/2a Dose Escalation and Expansion Study Evaluating Safety, Tolerability, Pharmacokinetic, Pharmacodynamics and Anti-Tumor Activity of PF-06873600 as a Single Agent and in Combination with Endocrine Therapy

Trial Description: Open-label, multi-center, non-randomized, multiple dose, safety, tolerability, pharmacokinetic, and pharmacodynamics and clinical activity study of PF-06873600 administered as a single agent and then in combination with endocrine therapy. The study contains two parts, a Part 1 single agent dose escalation and combination endocrine therapy dose finding component and a Part 2 dose expansion in combination with endocrine therapy

  • Conditions: hr+ her2- metastatic breast cancer ovarian cancer fallopian tube cancer primary peritoneal cancer triple negative breast cancer male breast cancer
  • Phase: I/II
  • Trial ID: NCT03519178
  • Protocol ID: 19-676

Enrolling

A phase I/Ib, open-label, multi-center, study of DKY709 as a single agent and in combination with PDR001 in patients with advanced solid tumors

Trial Description: This is a phase I/Ib, open label study. The escalation portion will characterize the safety and tolerability of DKY709 and DKY709 in combination with PDR001 in subjects with NSCLC or melanoma who have received prior anti-PD-1/PD-L1 therapy, or subjects with NPC. After the determination of the MTD/RD for a particular treatment arm, dose expansion will further assess safety, tolerability, PK/PD, and anti-tumor activity of each regimen at the MTD/RD

  • Conditions: carcinoma non-small-cell lung, melanoma, microsatellite stable colorectal cancer, nasopharyngeal carcinoma, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03891953
  • Protocol ID: 19-244

Enrolling

Phase 1/2a Dose Escalation, Finding and Expansion Study Evaluating Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Anti-Tumor Activity of PF-07104091 as a Single Agent and in Combination Therapy

Trial Description: To assess the safety and tolerability of increasing doses of PF-07104091 and to estimate the Maximum Tolerated Dose (MTD) and/or select the Recommended Phase 2 dose (RP2D) for PF-07104091 as a single agent in participants with small cell lung, non small cell lung, and ovarian and breast cancers.

  • Conditions: breast cancer, non small cell lung cancer, ovarian cancer, small cell lung cancer, triple-negative breast cancer
  • Phase: I/II
  • Trial ID: NCT04553133
  • Protocol ID: 20-537

Enrolling

P-RAD: A Randomized Study of Preoperative Chemotherapy, Pembrolizumab and No, Low or High Dose RADiation in Node-Positive, HER2-Negative Breast Cancer

Trial Description: This research trial is studying a combination of neoadjuvant radiotherapy (RT), immunotherapy (pembrolizumab) and chemotherapy for lymph node-positive, triple negative (TN) or hormone receptor positive/HER2-negative breast cancer. The names of the study interventions involved in this study are: - Radiation Therapy (RT) - Immunotherapy: Pembrolizumab (MK-3475) - Chemotherapies: - Paclitaxel - Doxorubicin (also called Adriamycin) - Cyclophosphamide - Carboplatin (optional, and in TN only) - Capecitabine (optional, and in TN only)

  • Conditions: biopsy-proven positive lymph node(s), hormone receptor positive (hr+) her2-negative breast cancer, triple negative breast cancer
  • Phase: Feasibility / Pilot
  • Trial ID: NCT04443348
  • Protocol ID: 20-157

Enrolling

A DOSE ESCALATION AND EXPANSION STUDY OF THE SAFETY AND PHARMACOKINETICS OF XL102 AS SINGLE-AGENT AND COMBINATION THERAPY IN SUBJECTS WITH INOPERABLE LOCALLY ADVANCED OR METASTATIC SOLID TUMORS

Trial Description: This is a Phase 1, open-label, dose-escalation and expansion study evaluating the safety, tolerability, PK, antitumor activity, and effect on biomarkers of XL102 administered orally alone and in multiple combination regimens to subjects with advanced solid tumors

  • Conditions: epithelial ovarian cancer, hormone receptor positive breast carcinoma, metastatic castration-resistant prostate cancer, neoplasm malignant, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT04726332
  • Protocol ID: 21-057

Enrolling

Screening MRI of the brain in patients with metastatic breast cancer managed with first/second line chemotherapy or inflammatory breast cancer managed with definitive intent: A prospective study

Trial Description: This research study is studying the usefulness of magnetic resonance imaging (MRI) to screen for brain metastases (spread of the breast cancer to the brain).

  • Conditions: breast cancer, her2-positive breast cancer, hormone receptor positive malignant neoplasm of breast, inflammatory breast cancer, metastatic breast cancer, triple negative breast cancer
  • Phase: II
  • Trial ID: NCT04030507
  • Protocol ID: 19-066

Enrolling

A PHASE IA/IB OPEN-LABEL, DOSE-ESCALATION STUDY OF THE SAFETY AND PHARMACOKINETICS OF RO7198457 AS A SINGLE AGENT AND IN COMBINATION WITH ATEZOLIZUMAB IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC TUMORS

Trial Description: This is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of autogene cevumeran (RO7198457) as a single agent and in combination with atezolizumab (MPDL3280A, an engineered anti-programmed death-ligand 1 [anti-PD-L1] antibody

  • Conditions: bladder cancer, colorectal cancer, head and neck cancer, melanoma, non-small cell lung cancer, other solid cancers, renal cancer, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03289962
  • Protocol ID: 18-051

Enrolling

A Phase 1, Open-Label, Multicenter Study of INCB106385 as Monotherapy or in Combination With Immunotherapy in Participants With Advanced Solid Tumors

Trial Description: This is a multicenter, open-label, dose-escalation/dose-expansion Phase 1 clinical study to investigate the safety, tolerability, PK profile, pharmacodynamics, and preliminary clinical efficacy of INCB106385 when given as monotherapy or in combination with INCMGA00012 in participants with selected CD8 T-cell-positive advanced solid tumors including SCCHN, NSCLC, ovarian cancer, CRPC, TNBC, or bladder cancer

  • Conditions: bladder cancer, castration resistant prostate cancer, non small cell lung cancer, ovarian cancer, squamous cell carcinoma of head and neck, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT04580485
  • Protocol ID: 21-076

Enrolling

A Phase 1, Open-Label, Multicenter, Dose Escalation Study of mRNA-2752, a Lipid Nanoparticle Encapsulating mRNAs Encoding Human OX40L, IL-23, and IL-36y, for Intratumoral Injection Alone and in Combination with Immune Checkpoint Blockade

Trial Description: The clinical study will assess the safety and tolerability of escalating intratumoral doses of mRNA-2752 in participants with relapsed/refractory solid tumor malignancies or lymphoma

  • Conditions: dose escalation: relapsed/refractory solid tumor malignancies or lymphoma, dose expansion: triple negative breast cancer head and neck squamous cell carcinoma non-hodgkin lymphoma and urothelial cancer
  • Phase: I
  • Trial ID: NCT03739931
  • Protocol ID: 18-518

Enrolling

A Phase 1b Dose-Escalation Study of Cabozantinib (XL184) Administered Alone or in Combination with Atezolizumab to Subjects with Locally Advanced or Metastatic Solid Tumors

Trial Description: This is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with atezolizumab in subjects with multiple tumor types, including advanced urothelial carcinoma (UC) (including bladder, renal pelvis, ureter, urethra), renal cell carcinoma (RCC), castration-resistant prostate cancer (CRPC), non-small-cell lung cancer (NSCLC), triple negative breast cancer (TNBC), ovarian cancer (OC), endometrial cancer (EC), hepatocellular cancer (HCC), gastric cancer/gastroesophageal

  • Conditions: castration-resistant prostate cancer, colorectal cancer, differentiated thyroid cancer, endometrial cancer, gastric cancer, gastroesophageal junction adenocarcinoma, head and neck cancer, hepatocellular carcinoma, lower esophageal cancer, non-small cell lung cancer, ovarian cancer, renal cell carcinoma, triple negative breast cancer, urothelial carcinoma
  • Phase: I
  • Trial ID: NCT03170960
  • Protocol ID: 17-492

Enrolling

A Phase 1b/2a Two-Part Open-Label Multicenter Study to Evaluate the Safety and Efficacy of LY2880070 as Monotherapy and in Combination with Gemcitabine in Patients with Advanced or Metastatic Cancer

Trial Description: The main purpose of this two-part study is to evaluate the safety and efficacy of the study drug known as LY2880070 in participants with advanced or metastatic solid tumors

  • Conditions: breast cancer, colon cancer, colorectal cancer, endometrial cancer, neoplasms, ovarian cancer, pancreas cancer, pancreatic cancer, rectal cancer, soft tissue sarcoma, solid tumors, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT02632448
  • Protocol ID: 18-524

Enrolling

A Phase 1, Open-Label, Multicenter, Dose Escalation and Expansion Study of ONCR-177, an Oncolytic Herpes Simplex Virus for Intratumoral Injection, Alone and in Combination with PD-1 Blockade in Adult Subjects with Advanced and/or Refractory Cutaneous, Subcutaneous or Metastatic Nodal Solid Tumors

Trial Description: ONCR-177-101 is a phase 1, open-label, multi-center, dose escalation and expansion study of ONCR-177, an oncolytic Herpes Simplex Virus for intratumoral injection, alone and in combination with PD-1 blockade in adult subjects with advanced and/or refractory cutaneous, subcutaneous or metastatic nodal solid tumors or with Liver Metastases of Solid Tumors. The purpose of this study is to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as well as to evaluate preliminary efficacy

  • Conditions: advanced solid tumor, breast cancer, cancer, colorectal carcinoma, liver metastases, melanoma, non-melanoma skin cancer, solid tumor, squamous cell carcinoma of head and neck, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT04348916
  • Protocol ID: 20-135

Not Enrolling

A Phase I, Open-Label, Dose Escalation Study of Oral LGK974 in Patients with Malignancies Dependent on Wnt Ligands

Trial Description: This primary purpose of this study is to find the recommended dose of LGK974 as a single agent and in combination with PDR001 that can be safely given to adult patients with selected solid malignancies for whom no effective standard treatment is available

  • Conditions: braf mutant colorectal cancer, cervical squamous cell cancer, esophageal squamous cell cancer, head and neck squamous cell cancer, lung squamous cell cancer, melanoma, pancreatic cancer, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT01351103
  • Protocol ID: 15-129

Enrolling

A Phase 1/2, First-In-Human, Multi-Part, Open-Label, Multiple-Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF6002 as a Monotherapy and in Combination with Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors

Trial Description: This study is a Phase 1/2, open-label, dose-escalation study with a consecutive parallel-group efficacy expansion study, designed to determine the safety, tolerability, PK, pharmacodynamics, and preliminary anti-tumor activity of DF6002 as monotherapy and in combination with nivolumab

  • Conditions: endometrial cancer, esophageal cancer, gastric cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, ovarian cancer, prostate cancer, renal cell carcinoma, solid tumor, triple negative breast cancer, urothelial carcinoma
  • Phase: I/II
  • Trial ID: NCT04423029
  • Protocol ID: 21-195

Not Enrolling

A Phase 1/1b Open-label, Dose-escalation and Dose-expansion Study of TPST-1120 as a Single Agent or in Combination with Systemic Anti-Cancer Therapies in Subjects with Advanced Solid Tumors

Trial Description: This is a phase 1/1b open label, multicenter dose escalation and dose expansion study to investigate the safety, tolerability and anti-tumor activity of TPST-1120, a small molecule selective antagonist of PPARα (peroxisome proliferator activated receptor alpha) as monotherapy and in combination with a systemic anticancer agent, nivolumab, an anti-PD1 antibody, in subjects with advanced solid tumors

  • Conditions: cholangiocarcinoma, colorectal cancer, gastroesophageal cancer, hepatocellular carcinoma, metastatic castration resistant prostate cancer, non-small cell lung cancer, pancreatic cancer, renal cell carcinoma, sarcoma, squamous cell carcinoma of head and neck, triple-negative breast cancer, urothelial carcinoma
  • Phase: I
  • Trial ID: NCT03829436
  • Protocol ID: 19-741

Enrolling

A MULTI-CENTER, OPEN LABEL PHASE 1/2 STUDY OF CYT-0851, AN ORAL RAD51 INHIBITOR, IN PATIENTS WITH RELAPSED/REFRACTORY B-CELL MALIGNANCIES AND ADVANCED SOLID TUMORS

Trial Description: This clinical trial is an interventional, active-treatment, open-label, multi-center, Phase 1/2 study. The study objectives are to assess the safety, tolerability and pharmacokinetics (PK) of the oral RAD51 inhibitor CYT-0851 in patients with relapsed/refractory B-cell malignancies and advanced solid tumors and to identify a recommended Phase 2 dose as a monotherapy and in combination with chemotherapy for evaluation in these patients

  • Conditions: breast cancer, cll, dlbcl, follicular lymphoma, head and neck cancer, malignancy, mantle cell lymphoma, multiple myeloma, non-hodgkin lymphoma, ovarian cancer, pancreatic cancer, small cell lung cancer, soft tissue sarcoma, squamous cell carcinoma of head and neck, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03997968
  • Protocol ID: 20-035

Not Enrolling

A PHASE 1/1b MULTICENTER STUDY TO EVALUATE THE HUMANIZED ANTI-CD73 ANTIBODY, CPI-006, AS A SINGLE AGENT, IN COMBINATION WITH CPI-444, AND IN COMBINATION WITH PEMBROLIZUMAB IN ADULT SUBJECTS WITH ADVANCED CANCERS

Trial Description: This is a Phase 1/1b open-label, dose escalation and dose expansion study of CPI-006, a humanized monoclonal antibody (mAb) targeting the CD73 cell-surface ectonucleotidase in adult subjects with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in combination with pembrolizumab (an anti-PD1 antibody), and in combination with ciforadenant and pembrolizumab.

  • Conditions: bladder cancer, cervical cancer, colorectal cancer, endometrial cancer, metastatic castration resistant prostate cancer, non-hodgkin lymphoma, non-small cell lung cancer, ovarian cancer, pancreatic cancer, renal cell cancer, sarcoma, squamous cell carcinoma of the head and neck, triple negative breast cancer
  • Phase: I
  • Trial ID: NCT03454451
  • Protocol ID: 18-335

Enrolling

First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFâ Fusion Protein BCA101 Alone and in Combination with Pembrolizumab in Patients with EGFR-Driven Advanced Solid Tumors

Trial Description: The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors

  • Conditions: anaplastic thyroid cancer, chordoma, colorectal cancer, egfr amplification, epithelial ovarian cancer, glioblastoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, kras g12d, kras g13d, pancreas cancer, squamous cell carcinoma of anal canal, squamous cell carcinoma of the lung, tnbc - triple-negative breast cancer, uveal melanoma
  • Phase: I
  • Trial ID: NCT04429542
  • Protocol ID: 20-147

Not Enrolling

A Phase 1/1b First-In-Human, Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IPI-549 Monotherapy and in Combination with Nivolumab in Subjects with Advanced Solid Tumors

Trial Description: This dose-escalation study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of IPI-549 monotherapy and IPI-549 in combination with nivolumab in subjects with advanced solid tumors

  • Conditions: adrenocortical carcinoma (part g), advanced solid tumors (part a/b/c/d), high-circulating myeloid-derived suppressor cells (part h), melanoma (part e), mesothelioma (part g), non-small cell lung cancer (part e), squamous cell cancer of the head and neck (part e), triple negative breast cancer (part f)
  • Phase: I
  • Trial ID: NCT02637531
  • Protocol ID: 16-008

Not Enrolling

A Phase 1 Multiple-Dose Study to Evaluate the Safety and Tolerability of XmAb®22841 Monotherapy and in Combination with Pembrolizumab in Subjects with Selected Advanced Solid Tumors (DUET-4)

Trial Description: This is a Phase 1, multiple dose, ascending-dose escalation study and expansion study designed to define a maximum tolerated dose and/or recommended dose of XmAb22841 monotherapy and in combination with pembrolizumab; to assess safety, tolerability, pharmacokinetics, immunogenicity, and anti-tumor activity of XmAb22841 monotherapy and in combination with pembrolizumab in subjects with select advanced solid tumors

  • Conditions: advanced or metastatic solid tumors, cervical carcinoma, colorectal carcinoma, endometrial carcinoma, epithelial ovarian cancer, fallopian tube cancer, gastric or gastroesophageal junction adenocarcinoma, hepatocellular carcinoma, intrahepatic cholangiocarcinoma, melanoma, nasopharyngeal carcinoma, non-small cell lung carcinoma, pancreatic carcinoma, primary peritoneal carcinoma, prostate carcinoma, renal cell carcinoma, small cell lung carcinoma, squamous cell anal cancer, squamous cell carcinoma of the head and neck, squamous cell penile carcinoma, squamous cell vulvar carcinoma, triple negative breast cancer, urothelial carcinoma
  • Phase: I
  • Trial ID: NCT03849469
  • Protocol ID: 19-300

Not Enrolling

A Multicenter, Phase 2 Study of Tesetaxel plus Three Different PD-(L)1 Inhibitors in Patients with Triple-Negative, Locally Advanced or Metastatic Breast Cancer and Tesetaxel Monotherapy in Elderly Patients with HER2 Negative, Locally Advanced or Metastatic Breast Cancer

Trial Description: CONTESSA TRIO is a multi-cohort, multicenter, Phase 2 study of tesetaxel, an investigational, orally administered taxane, in patients with metastatic breast cancer (MBC). In Cohort 1, approximately 200 patients with triple-negative MBC who have not received prior chemotherapy for advanced disease will be randomized 1:1:1 to receive tesetaxel plus either: (1) nivolumab; (2) pembrolizumab; or (3) atezolizumab. The primary efficacy endpoints for Cohort 1 are objective response rate (ORR) and progression free survival (PFS) in patients with programmed death-ligand 1 (PD-L1

  • Conditions: breast cancer
  • Phase: II
  • Trial ID: NCT03952325
  • Protocol ID: 19-170

Enrolling

Phase 1/2 Dose-Escalation and Expansion Study of FLX475 Alone and in Combination with Pembrolizumab in Advanced Cancer

Trial Description: This clinical trial is a Phase 1/2, open-label, sequential-group, dose-escalation and cohort expansion study to determine the safety and preliminary anti-tumor activity of FLX475 as monotherapy and in combination with pembrolizumab. The study will be conducted in 2 parts, a dose-escalation phase (Part 1) and a cohort expansion phase (Part 2). In Part 1 of the study, subjects will be enrolled in sequential cohorts treated with successively higher doses of FLX475 as monotherapy or in combination with pembrolizumab. In Part 2 of the study, subjects will be initially enrolled

  • Conditions: advanced cancer
  • Phase: I/II
  • Trial ID: NCT03674567
  • Protocol ID: 19-282

Not Enrolling

A phase 1, open-label, dose-escalation study to evaluate the safety and tolerability of SGN-LIV1A in patients with metastatic breast cancer.

Trial Description: This study will examine the safety and tolerability of ladiratuzumab vedotin (LV) in patients with metastatic breast cancer. LV will be given alone or in combination with trastuzumab.

  • Conditions: breast cancer
  • Phase: I
  • Trial ID: NCT01969643
  • Protocol ID: 14-306

Enrolling

A Modular Phase I, Open-Label, Multicentre Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Anti-tumour Activity of Ascending Doses of AZD6738 in combination with Cytotoxic Chemotherapy and/or DNA Damage Repair/Novel Anti-cancer Agents in Patients with Advanced Solid Malign

Trial Description: This is a modular, phase I/ phase 1 b, open-label, multicentre study of ceralasertib administered orally in combination with cytotoxic chemotherapy regimens and/or novel anti-cancer agents, to patients with advanced malignancies. The study design allows an investigation of optimal combination dose of ceralasertib with other anti-cancer treatments, with intensive safety monitoring to ensure the safety of the patients. The initial combination to be investigated is ceralasertib with carboplatin. The second combination to be investigated is ceralasertib with Olaparib. The third combination to be investigated is ceralasertib with durvalumab

  • Conditions: adv solid malig - h&n scc atm pro / def nsclc gastric breast and ovarian cancer
  • Phase: I
  • Trial ID: NCT02264678
  • Protocol ID: 18-342

Not Enrolling

A PHASE 3 OPEN-LABEL, RANDOMIZED, MULTICENTER STUDY OF NKTR-102 VERSUS TREATMENT OF PHYSICIAN’S CHOICE (TPC) IN PATIENTS WITH METASTATIC BREAST CANCER WHO HAVE STABLE BRAIN METASTASES AND HAVE BEEN PREVIOUSLY TREATED WITH AN ANTHRACYCLINE, A TAXANE, AND CAPECITABINE

Trial Description: This is an open-label, randomized, active comparator, multicenter, international Phase 3 study of NKTR-102 versus TPC in patients with metastatic breast cancer who have stable brain metastases and have been previously treated with an anthracycline, a taxane, and capecitabine in either the adjuvant or metastatic setting (prior anthracycline may be omitted if medically appropriate or contraindicated for the patient).

  • Conditions: breast cancer, metastasis
  • Phase: III
  • Trial ID: NCT02915744
  • Protocol ID: 16-553

Enrolling

A PHASE I/IIA, MULTI-CENTRE, OPEN-LABEL, DOSE-ESCALATION STUDY WITH EXPANSION ARMS TO ASSESS THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PRELIMINARY EFFICACY OF CB-103 ADMINISTERED ORALLY IN ADULT PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMOURS AND HAEMATOLOGICAL MALIGNANCIES CHARACTER

Trial Description: This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103

  • Conditions: adenoid cystic carcinoma, breast cancer, cholangiocellular carcinoma, colorectal cancer, desmoid tumour, glomus tumor malignant, non-hodgkin lymphoma, sarcoma
  • Phase: I/II
  • Trial ID: NCT03422679
  • Protocol ID: 20-746

Enrolling

"A Phase 2 Study of Cediranib in Combination with Olaparib in Advanced Solid Tumors

Trial Description: This phase II trial studies cediranib maleate in combination with olaparib in treating patients with solid tumors that have spread to other parts of the body (advanced/metastatic) or cannot be removed by surgery (unresectable), including breast cancer, non-small cell lung cancer, small cell lung cancer, and pancreatic cancer. Cediranib maleate and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Cediranib maleate may also block the flow of oxygen to the tumor, and may help make the tumor more sensitive to olaparib.

  • Conditions: metastatic lung non-small cell carcinoma, metastatic lung small cell carcinoma, metastatic pancreatic adenocarcinoma, metastatic triple-negative breast carcinoma, pancreatic ductal adenocarcinoma, stage iii breast cancer ajcc v7, stage iii lung non-small cell cancer ajcc v7, stage iii lung small cell carcinoma ajcc v7, stage iii pancreatic cancer ajcc v6 and v7, stage iiia breast cancer ajcc v7, stage iiia lung non-small cell cancer ajcc v7, stage iiia lung small cell carcinoma ajcc v7, stage iiib breast cancer ajcc v7, stage iiib lung non-small cell cancer ajcc v7, stage iiib lung small cell carcinoma ajcc v7, stage iiic breast cancer ajcc v7, stage iv breast cancer ajcc v6 and v7, stage iv lung non-small cell cancer ajcc v7, stage iv lung small cell carcinoma ajcc v7, stage iv pancreatic cancer ajcc v6 and v7, triple-negative breast carcinoma, unresectable lung small cell carcinoma, unresectable pancreatic adenocarcinoma, unresectable pancreatic carcinoma, unresectable triple-negative breast carcinoma
  • Phase: II
  • Trial ID: NCT02498613
  • Protocol ID: 18-714